Key result
Essential hypertension was associated with significantly altered aortic elasticity parameters compared to normotensive controls (p<0.01), which correlated with serum ET-1 levels (p=0.004).
Why the study?
Does blood pressure regulation status correlate with aortic stiffness and serum endothelin-1 levels in patients with essential hypertension?
Observational (n=152)
Does blood pressure regulation status correlate with aortic stiffness and serum endothelin-1 levels in patients with essential hypertension?
p-value: p=<0.01
Aortic elasticity parameters correlate with serum ET-1 levels and reflect blood pressure regulation status in patients with essential hypertension.
Aortic elasticity changes may mark ET-1 involvement in hypertension; leaves open causal and therapeutic implications.
This study has attempted to evaluate the relationship between aortic stiffness, blood pressure (BP) and serum endothelin-1 (ET-1) levels in patients with essential HT. Totally 152 subjects, consisting of 103 patients diagnosed with HT at least 1 year previously and 49 healthy individuals, were enrolled in this study. They were subdivided, on the basis of BP measurements made at home, into three groups as the hypertensives with dysregulated BP (n = 56), the hypertensives with regulated BP (n = 47) and the normotensive controls (n = 49). Statistically significant differences were observed between the three groups with respect to aortic elasticity parameters (p < 0.01 for aortic strain, aortic distensibility and aortic stiffness). Serum ET-1 levels in the three groups were similar (p = 0.101), but a significant correlation was observed between the ET-1 values and the aortic elasticity parameters (p = 0.004). Alteration of the aortic elasticity parameters in patients with HT not only correlates with the serum ET-1 levels indicating endothelial dysfunction but also gives direct clues about status of BP regulation.
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Nar et al. (2013) conducted an observational in Essential Hypertension (n=152). Essential hypertension (dysregulated or regulated blood pressure) vs. Normotensive controls was evaluated on Aortic elasticity parameters (aortic strain, distensibility, stiffness) (p=<0.01). Essential hypertension was associated with significantly altered aortic elasticity parameters compared to normotensive controls (p<0.01), which correlated with serum ET-1 levels (p=0.004).
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