In essentially hypertensive patients, women exhibit significantly higher augmentation index and central aortic pressure than men, suggesting sex-specific differences in arterial stiffness and atherosclerosis pathogenesis.
Should not yet alter arterial stiffness assessment in hypertension; cross-sectional data leave open need for sex-specific prognostic validation.
Hypertensive patients have strong evidence of endothelial dysfunction. We aimed to explore the relationships between cardiovascular risk factors and arterial stiffness parameters in hypertensive patients. The study population included 109 hypertensive patients (63 females, 46 males). Arterial stiffness measures including pulse wave velocity, augmentation index, and central aortic pressure were applied. Augmentation index and central aortic pressure were found to be significantly higher (P < .001 and P = .03, respectively) in women. The higher augmentation index and central aortic pressure values were observed in women than in men. These data offer new evidences for the role of sex hormones in the pathogenesis of atherosclerosis in women.
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Altun et al. (2012) studied this question.
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