March 2, 2018Frontiers in OncologyOpen Access

Cutaneous Angiosarcoma: The Possibility of New Treatment Options Especially for Patients with Large Primary Tumor

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Why the study?

Does concurrent chemoradiotherapy using taxanes improve survival in patients with large primary cutaneous angiosarcoma compared to conventional surgery and radiation?

Population

Patients with cutaneous angiosarcoma, particularly those with large primary tumors without distant metastasis.

Comparison

Concurrent chemoradiotherapy using taxanes… vs Conventional wide local excision surgery…

Design

Review

Authors

YFYasuhiro FujisawaEhime University KYKoji YoshinoChiba University TFTaku FujimuraTohoku University

Discussion

Member takes

Implication

Supports exploring taxane-based chemoradiotherapy for T2 CAS; leaves open whether it improves outcomes over standard care.

Structured PICO

Does concurrent chemoradiotherapy using taxanes improve survival in patients with large primary cutaneous angiosarcoma compared to conventional surgery and radiation?

Population

Patients with cutaneous angiosarcoma (CAS), particularly those with large primary tumors (T2, >5 cm) without distant metastasis.

Intervention

Concurrent chemoradiotherapy (CRT) using taxanes (paclitaxel or docetaxel) followed by maintenance chemotherapy.

Comparator

Conventional wide local excision surgery followed by postoperative radiation.

Outcome

Overall survival and tumor response rate.hard clinical

For patients with large primary cutaneous angiosarcoma, concurrent chemoradiotherapy with taxanes followed by maintenance chemotherapy may offer better survival outcomes than conventional mutilating surgery.

Limitations

Rarity of the disease prevents large randomized phase-3 trials
Most clinical trials of new drugs do not include sufficient numbers of CAS patients

Cite This Study

Fujisawa et al. (2018) studied this question.

synapsesocial.com/papers/6a729c33febe604dd70ab00c https://doi.org/10.3389/fonc.2018.00046

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Cutaneous Angiosarcoma: The Possibility of New Treatment Options Especially for Patients with Large Primary Tumor

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Cutaneous Angiosarcoma: The Possibility of New Treatment Options Especially for Patients with Large Primary Tumor

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider