Population
Cultured rat vascular smooth muscle cells (SMC)
Design
Preclinical
Authors
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Suggests cGMP-mediated C-receptor downregulation in vascular cells; leaves open its relevance to human cardiovascular signaling or therapy.
Natriuretic peptides downregulate the C-receptor in vascular smooth muscle cells through the activation of the ANP-B receptor-cGMP pathway rather than direct C-receptor binding.
Kishimoto et al. (1993) studied this question.
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