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March 1, 2002Clinical and Vaccine ImmunologyOpen Access

Opsonophagocytosis of Fluorescent Polystyrene Beads Coupled to Neisseria meningitidis Serogroup A, C, Y, or W135 Polysaccharide Correlates with Serum Bactericidal Activity

Joseph Martinez Tamara Pilishvili Suzanne Barnard Joseph Caba Willie Spear Sandra Romero‐Steiner George M. Carlone

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Abstract

We developed a polysaccharide-specific flow cytometric opsonophagocytic assay (OPA) for the simultaneous measurement of functional antibody to Neisseria meningitidis serogroups A, C, Y, and W135. OPA titers significantly correlated with serum bactericidal assay titers for all serogroups tested (mean r = 0.96; P < 0.001). OPA could be used in meningococcal vaccine evaluation.

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synapsesocial.com/papers/6a729e5826770c2b8de1842a https://doi.org/10.1128/cdli.9.2.485-488.2002

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