Why the study?
Does asymmetric isosorbide dinitrate treatment improve hemodynamics without inducing nitrate tolerance in patients with stable ischemic heart disease?
Population
14 patients with stable ischemic heart disease and impaired left ventricular function during exercise
Comparison
Isosorbide dinitrate 30 mg asymmetrically b.i.d… vs Placebo asymmetrically b.i.d. for 4 weeks
Design
RCT, randomized, double-blinded
Follow-up
4 weeks
Authors
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Asymmetric ISDN dosing lowers exercise PAWP/MAP in stable IHD; confirms partial nitrate tolerance develops despite asymmetric regimen.
Does asymmetric isosorbide dinitrate treatment improve hemodynamics without inducing nitrate tolerance in patients with stable ischemic heart disease?
Asymmetric dosing of isosorbide dinitrate improves hemodynamics in patients with stable ischemic heart disease but still induces a definite, partial nitrate tolerance.
Jørgensen et al. (1994) studied this question.
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