Why the study?
How can the development of nitrate tolerance be minimized in patients treated for angina pectoris?
How can the development of nitrate tolerance be minimized in patients treated for angina pectoris?
Incorporating a nitrate-free interval is an effective strategy to restore vascular responsiveness and prevent nitrate tolerance in patients with angina pectoris.
Nitrate-free intervals may minimize tolerance in angina; leaves open optimal regimens for prospective trials.
A review of the current literature concerning development of nitrate tolerance in the treatment of angina pectoris suggests that: development of nitrate tolerance is a clinical reality development of tolerance do not seem to differ for nitroglycerin, isosorbide-dinitrate or isosorbide-5-mononitrate a high nitrate dose seems to be more likely to induce tolerance a nitrate free interval during some part of the day or the night seems to restore vascular responsiveness by optimal use of different nitrate formulations the problem with development of tolerance may be reduced.
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Rolf Nordlander (1986) studied this question.
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