Why the study?
This review was conducted to update existing knowledge regarding the pharmacology of direct oral anticoagulants (DOACs), their comparison with traditional anticoagulants, drug interactions, application errors, and the usage of reversal agents.
This review provides an update on the pharmacology, efficacy, safety, drug interactions, and use of reversal agents for direct oral anticoagulants compared to traditional anticoagulants.
This review is devoted to updating the existing knowledge about pharmacology of the drugs from the group of direct oral anticoagulants (DOACs). Special attention is paid to comparison of the anticoagulant properties of DOACs with traditional (indirect) anticoagulants at various dosage regimens and to study drug interactions of DOACs with drugs from different pharmacological groups. Widely analyzed the side effects associated with errors in the application of DOACs and provided recommendations for their correction, including the using of reversal agents therapy. Based on this, the presented article will be useful to clinicians to familiarize themselves with modern medical strategies based on the use of drugs from the DOACs group for the prevention and treatment of diseases associated with increased blood clotting ability and using of DOACs specific antagonists for treatment overdose of DOACs.
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Tarasov et al. (2019) studied this question.
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