Key result
This review discusses the mechanisms of action, pharmacodynamics, drug interactions, adverse reactions, and principles of selecting direct oral anticoagulants in modern clinical practice.
This review summarizes the clinical pharmacology, mechanisms, interactions, and safety profiles of direct oral anticoagulants in modern practice.
The article considers clinical and pharmacological approaches to rational pharmacotherapy with direct oral anticoagulants (DOAC). The main issues of the mechanism of action, pharmacodynamics, and interaction of these medicines, as well as adverse reactions and, consequently, risks associated with taking DOAC, and the principles of selecting direct oral anticoagulants are discussed. The materials are presented on the basis of modern data from domestic and foreign literature.
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Kadyseva et al. (2020) reported a review. Direct oral anticoagulants (DOAC) was evaluated. This review discusses the mechanisms of action, pharmacodynamics, drug interactions, adverse reactions, and principles of selecting direct oral anticoagulants in modern clinical practice.
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