Why the study?
Does the beta-adrenergic blocking agent I.C.I. 66,082 reduce blood pressure and alter haemodynamics in hypertensive patients?
Does the beta-adrenergic blocking agent I.C.I. 66,082 reduce blood pressure and alter haemodynamics in hypertensive patients?
Treatment with the beta-blocker I.C.I. 66,082 for one month effectively reduced mean arterial blood pressure in hypertensive patients.
Answers are grounded in this paper and cite their sources.
Supports short-term BP reduction in hypertension; leaves open confirmation of haemodynamics and outcomes in randomized trials.
SummaryHaemodynamic studies were performed in 11 hypertensive patients, first while they were receiving placebo and then after one months treatment with a beta-adrenergic blocking agent (I.C.I. 66,082).An average fall in mean arterial blood pressure of 26.2 mmHg was obtained. Although the mean total peripheral resistance showed little change, data from individual patients show a correlation between changes in blood pressure and resistance. There was no correlation between fall in pressure and fall in cardiac output.
No takes yet. Share an insight, caveat, or question.
Amery et al. (1973) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: