Why the study?
Does placing an isovolumic balloon in the left ventricle improve coronary reflow after global ischemia in isolated rat hearts?
Population
Isolated rat hearts subjected to 60 minutes of global ischemia
Comparison
Placement of a fluid-filled isovolumic balloon… vs Hearts without the left ventricular balloon
Design
Preclinical
Follow-up
60 minutes of ischemia
Authors
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May implicate wall tension in no-reflow pathogenesis; hypothesis-generating in this model and leaves clinical translation open.
Does placing an isovolumic balloon in the left ventricle improve coronary reflow after global ischemia in isolated rat hearts?
Maintaining an isovolumic left ventricle during global ischemia significantly reduces the no-reflow zone, supporting the concept that intramyocardial pressure from ischemic contracture drives the no-reflow phenomenon.
Humphrey et al. (1981) studied this question.
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