Complications and related risk factors in Uygur patients with type 2 diabetes mellitus

Objective To investigate the prevalence of complication and related risk factors in Uygur patients with type 2 diabetes mellitus (T2DM). Methods Total 1 507 Uygur patients aged above 20 with T2DM were recruited in the First Affiliated Hospital of Xinjiang Medical University from January 2010 to October 2015. Clinical characteristics, biochemical parameters and related complications were analyzed in different age groups of patients. Multivariate logistic regression was performed to determine associated factors for diabetic complications. Results Among 1 507 cases, there were 61.3% male patients (n=924), 37.4% (n=564) with diabetes duration ≥5 years, 12.5% (n=189) with HbA1c>10%, 31.5% (n=475) with hypertension, 28.8% (n=434) with smoking history and 37.4% (n=564) patients without antidiabetic drug treatment. The average body mass index (BMI) of patients was (27.4±5.2) kg/m2 with a obesity rate of 43.0% (648/1 507), and 65.0% (980/1 507) had physical exercise 10% (OR=2.74, 95%CI: 1.40-5.34), obesity (OR=1.54, 95%CI: 1.07-2.21), systolic pressure≥140 mmHg (1 mmHg=0.133 kPa) (OR=1.42, 95%CI: 1.01-1.99), diastolic pressure≥90 mmHg (OR=0.37, 95%CI: 0.21-0.67), smoking (OR=1.53, 95%CI: 1.09-2.15) and physical activity<150 min/week (OR=1.42, 95%CI: 1.07-1.89) were the risk factors of diabetic complications. Conclusion Uygur patients with type 2 diabetes in Xinjiang show a relatively high prevalence of complications.Poor glycemic control,obesity,hypertension,smoking and physical inactivity may contribute to development of complications, while well-controlled blood glucose and hypertension and quitting smoking and increasing physical activity may reduce diabetic complications.