What question did this study set out to answer?

To evaluate whether combining donepezil with the cholinergic precursor choline alphoscerate counters apathy more effectively than donepezil monotherapy over two years in Alzheimer's disease.

September 9, 2015Journal of Alzheimer s Disease

Apathy Treatment in Alzheimer’s Disease: Interim Results of the ASCOMALVA Trial

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Authors

RRRaffaele ReaOspedale Antonio Cardarelli ACAnna CarotenutoOspedale Antonio Cardarelli ETEnea TrainiUniversità di Camerino

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Implication

Clinical trial demonstrates reduced apathy in Alzheimer disease with donepezil and choline alphoscerate, indicating that elevating acetylcholine improves motivation.

Key Points

To evaluate whether combining donepezil with the cholinergic precursor choline alphoscerate counters apathy more effectively than donepezil monotherapy over two years in Alzheimer's disease.
Assessed 113 patients with mild-to-moderate Alzheimer's disease across two matched treatment arms: donepezil plus choline alphoscerate (n=56) versus donepezil alone (n=57).
Evaluated apathy and caregiver distress at baseline and months 3, 6, 9, 12, 18, and 24 using the Neuropsychiatric Inventory apathy subtest, alongside baseline executive function testing via the Frontal Assessment Battery.
Patients receiving the combination therapy showed significantly lower apathy scores from 12 to 24 months and reduced caregiver distress from 6 to 24 months compared to donepezil monotherapy.
Improvements in apathy occurred independently of global cognitive performance (MMSE and ADAS-cog) and were significantly greater in participants with preserved baseline frontal executive functions.

Cite This Study

Rea et al. (2015) studied this question.

synapsesocial.com/papers/6a72a6b7a528af2d65c47d12 https://doi.org/10.3233/jad-141983

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Implication

Clinical trial demonstrates reduced apathy in Alzheimer disease with donepezil and choline alphoscerate, indicating that elevating acetylcholine improves motivation.

Apathy Treatment in Alzheimer’s Disease: Interim Results of the ASCOMALVA Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Apathy Treatment in Alzheimer’s Disease: Interim Results of the ASCOMALVA Trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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