What question did this study set out to answer?

To evaluate whether three months of methylphenidate therapy reduces psychopathic behavior in children diagnosed with ADHD with or without comorbid oppositional defiant disorder.

June 29, 2018International Clinical Psychopharmacology

The effect of methylphenidate treatment on psychopathic behavior of patients having attention-deficit hyperactivity disorder with and without oppositional defiant disorder

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Authors

PGPavel GolubchikTel Aviv University TLTomer LevyColumbia University Irving Medical Center AWAbraham WeizmanTel Aviv University

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Implication

Comparative study reveals methylphenidate reduces psychopathic traits in youth with ADHD and oppositional defiant disorder, indicating a behavioral benefit linked to attention gains.

Key Points

To evaluate whether three months of methylphenidate therapy reduces psychopathic behavior in children diagnosed with ADHD with or without comorbid oppositional defiant disorder.
Assessed 27 children with DSM-5 ADHD (13 female, 14 male; mean age 13.3±2.2 years) alongside 27 age- and sex-matched children with comorbid ADHD and ODD (8 female, 19 male; mean age 11.8±1.9 years).
Administered methylphenidate at doses of 0.8–1.2 mg/kg/day over a 3-month treatment period.
Measured symptom severity at baseline and follow-up using the ADHD Rating Scale (ADHD-RS) and the California Child Q-Set (CCQ).
ADHD-RS scores decreased significantly in both the ADHD/ODD group (P<0.0011) and the ADHD-alone group (P=0.0012).
CCQ scores reflecting psychopathic behavior improved significantly in the ADHD/ODD group (P=0.0001) but showed no significant change in the ADHD-alone group (P=0.18).
Reductions in ADHD-RS and CCQ scores were positively correlated within the ADHD/ODD cohort (Spearman's r=0.43, P=0.024).

Cite This Study

Golubchik et al. (2018) studied this question.

synapsesocial.com/papers/6a72a74bfe4101aa97e0e68d https://doi.org/10.1097/yic.0000000000000231

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Implication

Comparative study reveals methylphenidate reduces psychopathic traits in youth with ADHD and oppositional defiant disorder, indicating a behavioral benefit linked to attention gains.

The effect of methylphenidate treatment on psychopathic behavior of patients having attention-deficit hyperactivity disorder with and without oppositional defiant disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

The effect of methylphenidate treatment on psychopathic behavior of patients having attention-deficit hyperactivity disorder with and without oppositional defiant disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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