Why the study?
Does once daily atenolol reduce blood pressure as effectively as twice daily dosing in hypertensive patients?
Does once daily atenolol reduce blood pressure as effectively as twice daily dosing in hypertensive patients?
Once daily atenolol 100 mg is as effective as twice daily dosing for reducing blood pressure in hypertensive patients.
Supports once-daily atenolol 100 mg for hypertension; confirms equivalent efficacy to twice-daily regimens in this RCT.
The hypertensive action of atenolol has been studied in a randomized double-blind crossover comparison. Twelve patients showed a highly significant reduction in average supine systolic and diastolic blood pressures from pre-treatment values of 196.3/115.9 to 159.1/89.2 mmHg (26.1/15.4 kPa to 22.2/11.9 kPa) after 2 weeks on once daily atenolol. No dose-related reduction in blood pressure was seen and the single 100 mg daily dose was as effective as 100 mg twice daily or 50 mg twice daily. Blood pressures recorded after 2 weeks' atenolol were lower than those obtained at 7 days irrespective of dose.
No takes yet. Share an insight, caveat, or question.
Castleden et al. (1977) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: