Why the study?
Do arterial vasodilators (hydralazine or minoxidil) affect cardiac hypertrophy and sympathetic activity in spontaneously hypertensive and normotensive rats?
Population
Spontaneously hypertensive rats (SHR) and normotensive rats
Design
Preclinical
Follow-up
5 weeks
Authors
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Minoxidil may promote sympathetic-driven hypertrophy in rat models; leaves open relevance to human arterial vasodilator therapy.
Do arterial vasodilators (hydralazine or minoxidil) affect cardiac hypertrophy and sympathetic activity in spontaneously hypertensive and normotensive rats?
Arterial vasodilators induce persistent cardiac sympathetic hyperactivity and, particularly with minoxidil, chronic cardiac volume overload leading to cardiac hypertrophy in rat models.
Tsoporis et al. (1988) studied this question.
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