November 27, 2014Thrombosis and Haemostasis

Impact of variables of the P-selectin – P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease

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Population

263 patients undergoing angioplasty and stenting

Design

Cohort

Authors

RKRenate KoppensteinerVascular Medicine AKAlexandra KaiderVascular Medicine BEBeate EichelbergerMedical University of Vienna

Discussion

Member takes

Implication

pP-selectin contributes modestly to post-angioplasty MPA/NPA formation irrespective of alleles; observational data leave open therapeutic relevance.

Structured PICO

Population

263 patients undergoing angioplasty and stenting

Outcome

Monocyte-platelet aggregates (MPA) and neutrophil-platelet aggregates (NPA) formationsurrogate

Platelet P-selectin plays a significant role in monocyte- and neutrophil-platelet aggregate formation in patients undergoing angioplasty, while sP-selectin and genetic variants have less influence.

Cite This Study

Koppensteiner et al. (2014) studied this question.

synapsesocial.com/papers/6a72a7e135aa2c282ce35d62 https://doi.org/10.1160/th14-08-0690

Topics

Women and heart disease

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Implication

pP-selectin contributes modestly to post-angioplasty MPA/NPA formation irrespective of alleles; observational data leave open therapeutic relevance.

Impact of variables of the P-selectin – P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Impact of variables of the P-selectin – P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider