January 1, 1997Arteriosclerosis Thrombosis and Vascular Biology
Inhibition of Collagen Synthesis, Smooth Muscle Cell Proliferation, and Injury-Induced Intimal Hyperplasia by Halofuginone
Why the study?
Does halofuginone reduce smooth muscle cell proliferation and injury-induced intimal hyperplasia in preclinical models?
Population
In vitro bovine aortic endothelial cells and smooth muscle cells, and in vivo rabbit ear model of crush…
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for halofuginone in restenosis prevention; leaves open translation to human arterial injury models.
Structured PICO
Does halofuginone reduce smooth muscle cell proliferation and injury-induced intimal hyperplasia in preclinical models?
P
Population
In vitro bovine aortic endothelial cells and smooth muscle cells (SMCs), and in vivo rabbit ear model of crush injury-induced arterial intimal hyperplasia
I
Intervention
Halofuginone (in vitro: ≥0.1 microgram/mL; in vivo: local administration)
O
Outcome
Proliferation of vascular SMCs and endothelial cells, extracellular matrix deposition, collagen type I synthesis, and injury-induced intimal hyperplasia (neointima/media ratio)surrogate
Halofuginone inhibits vascular smooth muscle cell proliferation and extracellular matrix deposition, significantly reducing injury-induced intimal hyperplasia in a rabbit model, suggesting potential for preventing arterial restenosis.
Cite This Study
Nagler et al. (1997) studied this question.