What question did this study set out to answer?

Summarize the cellular and molecular mechanisms that govern polarized protein trafficking and the maintenance of distinct plasma membrane domains in kidney epithelial cells.

January 1, 1996Physiological Reviews

Protein trafficking and polarity in kidney epithelium: from cell biology to physiology

View Full Paper

Ask AI

Bookmark

Authors

DBDennis BrownMassachusetts General Hospital JSJennifer L. StowThe University of Queensland

Discussion

Member takes

Implication

Narrative review reveals mechanisms of polarized protein trafficking in renal epithelial cells, highlighting how sorting breakdowns contribute to kidney diseases.

Key Points

Summarize the cellular and molecular mechanisms that govern polarized protein trafficking and the maintenance of distinct plasma membrane domains in kidney epithelial cells.
Narrative synthesis of cellular mechanisms directing the selective insertion and recycling of membrane proteins and lipids in renal epithelia.
Evaluation of targeting signals, cytoskeletal elements, tight junction barriers, GTP-binding proteins, and vesicle fusion machinery across kidney cell types.
Transepithelial transport relies on the precise, selective targeting of transporters, enzymes, and channels to either apical or basolateral plasma membrane domains.
Polarized membrane organization is orchestrated by intrinsic peptide targeting signals, cytoskeletal networks, tight junctions, and GTP-dependent vesicle docking complexes.
Disruptions in polarized protein delivery, vesicle fusion, or membrane domain maintenance directly precipitate specific renal disease states.

Cite This Study

Brown et al. (1996) studied this question.

synapsesocial.com/papers/6a72ab09fe4101aa97e0e84a https://doi.org/10.1152/physrev.1996.76.1.245

View Full Paper

Ask AI

Bookmark

Implication

Narrative review reveals mechanisms of polarized protein trafficking in renal epithelial cells, highlighting how sorting breakdowns contribute to kidney diseases.

Protein trafficking and polarity in kidney epithelium: from cell biology to physiology

Discussion

Member takes

Implication

Key Points

Cite This Study

Protein trafficking and polarity in kidney epithelium: from cell biology to physiology

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider