A novel mathematical model incorporating cerebral cortex activity can adequately simulate cardiovascular dynamics during different stages of sleep and wakefulness.
May inform simulations of cortical modulation of cardiovascular control during sleep; leaves open empirical validation before research use.
We propose a mathematical model of the human cardiovascular system. The model allows one to simulate the main heart rate, its variability under the influence of the autonomic nervous system, breathing process, and oscillations of blood pressure. For the first time, the model takes into account the activity of the cerebral cortex structures that modulate the autonomic control loops of blood circulation in the awake state and in various stages of sleep. The adequacy of the model is demonstrated by comparing its time series with experimental records of healthy subjects in the SIESTA database. The proposed model can become a useful tool for studying the characteristics of the cardiovascular system dynamics during sleep.
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Karavaev et al. (2021) studied this question.
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