What question did this study set out to answer?

To determine the independent effects of anemia and comorbidity on functional decline and mortality in very old age.

May 1, 1997GutOpen Access

The genetics of inflammatory bowel disease.

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Authors

JSJack SatsangiNuffield Orthopaedic Centre DJD P JewellGuy's Hospital JBJ I BellStanford University

Discussion

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Overview

Prospective cohort study shows that anemia increases mortality risk in elderly individuals, indicating that comorbidity drives functional decline while anemia independently raises mortality.

Key Points

To determine the independent effects of anemia and comorbidity on functional decline and mortality in very old age.
Population-based prospective follow-up study (Leiden 85-plus Study) evaluating 562 individuals aged 85 years over 5 years of annual follow-up.
Assessed anemia by WHO criteria and functional status via basic and instrumental activities of daily living, cognitive tests, and depressive symptoms.
Evaluated all-cause mortality using municipal registry data, adjusting for sex, education, income, long-term care residence, C-reactive protein, creatinine clearance, and comorbidity.
Baseline anemia was present in 26.7% (150/562) of participants and associated with worse functional, cognitive, and depressive scores (p ≤ 0.01), but these associations were attenuated after adjusting for comorbidity.
In longitudinal analyses adjusted for comorbidity, baseline anemia predicted worsening instrumental disability, whereas incident anemia (n = 99) predicted accelerated disability in basic activities of daily living.
Both prevalent anemia (hazard ratio 1.41, 95% CI 1.13 to 1.76) and incident anemia (hazard ratio 2.08, 95% CI 1.60 to 2.70) independently increased the risk of mortality.

Cite This Study

Satsangi et al. (1997) studied this question.

synapsesocial.com/papers/6a72abe626a7f98052de6a13 https://doi.org/10.1136/gut.40.5.572

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May 1, 1997GutOpen Access

The genetics of inflammatory bowel disease.

View Full Paper

Ask AI

Bookmark

Authors

JSJack SatsangiNuffield Orthopaedic Centre DJD P JewellGuy's Hospital JBJ I BellStanford University

Discussion

Member takes

Overview

Prospective cohort study shows that anemia increases mortality risk in elderly individuals, indicating that comorbidity drives functional decline while anemia independently raises mortality.

Key Points

To determine the independent effects of anemia and comorbidity on functional decline and mortality in very old age.
Population-based prospective follow-up study (Leiden 85-plus Study) evaluating 562 individuals aged 85 years over 5 years of annual follow-up.
Assessed anemia by WHO criteria and functional status via basic and instrumental activities of daily living, cognitive tests, and depressive symptoms.
Evaluated all-cause mortality using municipal registry data, adjusting for sex, education, income, long-term care residence, C-reactive protein, creatinine clearance, and comorbidity.
Baseline anemia was present in 26.7% (150/562) of participants and associated with worse functional, cognitive, and depressive scores (p ≤ 0.01), but these associations were attenuated after adjusting for comorbidity.
In longitudinal analyses adjusted for comorbidity, baseline anemia predicted worsening instrumental disability, whereas incident anemia (n = 99) predicted accelerated disability in basic activities of daily living.
Both prevalent anemia (hazard ratio 1.41, 95% CI 1.13 to 1.76) and incident anemia (hazard ratio 2.08, 95% CI 1.60 to 2.70) independently increased the risk of mortality.

Cite This Study

Satsangi et al. (1997) studied this question.

synapsesocial.com/papers/6a72abe626a7f98052de6a13 https://doi.org/10.1136/gut.40.5.572

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