Population
Xenopus oocytes heterologously expressing HERG channels (including wild-type and D540K mutation)
Comparison
8 HERG channel blockers applied at different… vs Different pulsing frequencies and voltage states
Design
Preclinical
Authors
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HERG blocker dissociation kinetics may influence proarrhythmic risk assessment; leaves open refined quantification in preclinical screening.
HERG channel blockers exhibit distinct state-dependent dissociation kinetics (from open vs. resting states), which may impact the accurate quantification of HERG block and proarrhythmic risk.
Stork et al. (2007) studied this question.
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