Why the study?
Does perindopril reduce serum ADMA and plasma vWF in patients with uncomplicated type 2 diabetes mellitus?
Population
11 patients with type 2 diabetes mellitus not treated with insulin or oral hypoglycemic drugs and without…
Comparison
Perindopril 4 mg/day for 4 weeks vs Crossover control (baseline)
Design
Other
Follow-up
4 weeks
Authors
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Suggests possible endothelial benefit of perindopril in T2DM independent of BP/glucose; leaves open clinical outcome impact.
Does perindopril reduce serum ADMA and plasma vWF in patients with uncomplicated type 2 diabetes mellitus?
ACE inhibition with perindopril reduces ADMA and vWF levels in uncomplicated type 2 diabetes, suggesting a role for ACE in endothelial dysfunction.
Ito et al. (2002) studied this question.
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