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November 20, 2023SLEEPOpen Access

Emerging research on circadian misalignment and cardiometabolic health of adolescents

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Why the study?

Does circadian misalignment exacerbate the association between visceral adiposity and metabolic syndrome in adolescents?

Design

Editorial commentary

Authors

LHLauren HaleStony Brook SchoolGMGina Marie MathewStony Brook School

Discussion

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Overview

Circadian misalignment may amplify visceral adiposity–metabolic syndrome links in adolescents; hypothesis-generating and requires prospective confirmation.

Structured PICO

Does circadian misalignment exacerbate the association between visceral adiposity and metabolic syndrome in adolescents?

P
Population
Adolescents (mean age = 16 years) from the Pennsylvania State Cohort
I
Intervention
Circadian misalignment (actigraphic assessment of sleep midpoint, variability of sleep midpoint, and social jetlag)
C
Comparator
Adolescents without circadian misalignment
O
Outcome
Association between visceral adiposity and metabolic syndrome (measured via waist circumference, mean arterial pressure, homeostasis model assessment of insulin resistance, triglycerides, and high-density lipoprotein)surrogate

Circadian misalignment exacerbates the association between visceral adiposity and metabolic syndrome in adolescents, highlighting sleep regularity as a potential modifiable target for cardiometabolic health.

Limitations

  • Unable to account for sociodemographic, family, and contextual factors that may confound associations
  • Did not investigate the physiological mechanisms
  • Did not investigate the longitudinal associations of visceral adiposity and circadian misalignment with metabolic syndrome

Cite This Study

Hale et al. (2023) studied this question.

synapsesocial.com/papers/6a72b419fe4101aa97e0eaa4https://doi.org/10.1093/sleep/zsad291
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association2022 · 2,738 citations
  2. 2Circadian misalignment impacts the association of visceral adiposity with metabolic syndrome in adolescents2023 · 19 citations
  3. 3Sleep duration and social jetlag are independently associated with anxious symptoms in adolescents2019 · 85 citations
  4. 4Worse sleep health predicts less frequent breakfast consumption among adolescents in a micro-longitudinal analysis2022 · 15 citations
  5. 5Sex Moderates Relationships Among School Night Sleep Duration, Social Jetlag, and Depressive Symptoms in Adolescents2019 · 63 citations