The Cephalic Insulin Response to Meal Ingestion in Humans Is Dependent on Both Cholinergic and Noncholinergic Mechanisms and Is Important for Postprandial Glycemia
Why the study?
Does autonomic blockade with trimethaphan or atropine reduce the cephalic insulin response to meal ingestion in healthy women?
Population
12 healthy women, mean age 63 +/- 0.4 years, BMI 27.7 +/- 1.7 kg/m2
Comparison
Trimethaphan or atropine given intravenously… vs Saline given intravenously during the first 15…
Follow-up
60 minutes
Authors
Discussion
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Member takes
Implication
Autonomic blockade attenuates cephalic insulin secretion; leaves open its contribution to postprandial glucose tolerance and requires confirmation in larger studies.
Structured PICO
Does autonomic blockade with trimethaphan or atropine reduce the cephalic insulin response to meal ingestion in healthy women?
P
Population
12 healthy women, mean age 63 +/- 0.4 years, BMI 27.7 +/- 1.7 kg/m2
I
Intervention
Trimethaphan or atropine given intravenously during the first 15 min after ingestion of a standard meal (350 kcal)
C
Comparator
Saline given intravenously during the first 15 min after ingestion of a standard meal
O
Outcome
Preabsorptive 10-min insulin response and glucose levels from 25 to 60 min after meal ingestionsurrogate
The early preabsorptive insulin response to meal ingestion is largely mediated by autonomic activation and is required for normal postprandial glucose tolerance.
Cite This Study
Åhrén et al. (2001) studied this question.