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August 1, 1990Circulation ResearchOpen Access

Exacerbation of reperfusion arrhythmias by sudden oxidant stress.

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Why the study?

Does a sudden burst of oxidant stress exacerbate reperfusion arrhythmias in rat hearts?

Population

Rat hearts (n = 12/group) subjected to regional ischemia and reperfusion

Comparison

Rose bengal added to perfusion fluid before… vs Hearts with regional ischemia and reperfusion in…

Design

Preclinical

Follow-up

5 minutes of reperfusion

Authors

YKYoshiki KusamaOsaka University HospitalMBMichèle BernierInstitut de Radioprotection et de Sûreté NucléaireDHDavid J. HearseCross-Cutting Cardiology

Discussion

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Member takes

Overview

Oxidant stress may exacerbate reperfusion arrhythmias; leaves open translation from rat model to clinical relevance.

Structured PICO

Does a sudden burst of oxidant stress exacerbate reperfusion arrhythmias in rat hearts?

P
Population
Rat hearts (n = 12/group) subjected to regional ischemia and reperfusion
I
Intervention
Rose bengal (1 mumol/l) added to perfusion fluid before ischemia, followed by uniform illumination (8,500 lux) with green light (530-590 nm) during the first 30 seconds of reperfusion to induce a burst of oxidant stress
C
Comparator
Hearts with regional ischemia and reperfusion in the absence of rose bengal and/or illumination
O
Outcome
Incidence of reperfusion arrhythmias (ventricular premature beats, ventricular tachycardia, ventricular fibrillation)surrogate

A sudden burst of oxidant stress during the early moments of reperfusion significantly exacerbates the vulnerability to reperfusion arrhythmias in a rat heart model.

Cite This Study

Kusama et al. (1990) studied this question.

synapsesocial.com/papers/6a72b597febe604dd70abb95https://doi.org/10.1161/01.res.67.2.481
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Also Consider

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  1. 1LASER FLASH PHOTOKINETIC STUDIES OF ROSE BENGAL SENSITIZED PHOTODYNAMIC INTERACTIONS OF NUCLEOTIDES AND DNA1987 · 274 citations
  2. 2Influence of oxygen radicals generated by xanthine oxidase in the isolated perfused rat heart1986 · 91 citations
  3. 3Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles.1986 · 242 citations
  4. 4The Indian happiness wart in the development of photodynamic action1987 · 42 citations