What question did this study set out to answer?

To evaluate the complementary performance of 18F-FAPI PET/CT compared with 18F-FDG PET/CT and MRI for diagnosing recurrent hepatocellular carcinoma and extrahepatic metastases.

September 1, 2022Cancer Management and ResearchOpen Access

Different Features of 18F-FAPI, 18F-FDG PET/CT and MRI in the Evaluation of Extrahepatic Metastases and Local Recurrent Hepatocellular Carcinoma (HCC): A Case Report and Review of the Literature

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Authors

DCDonghe ChenBeijing Transportation Research Center CCChengdong ChangFirst Affiliated Hospital Zhejiang University YZYafei ZhangNorth China University of Water Resources and Electric Power

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Implication

Case report reveals 18F-FAPI PET/CT improves peritoneal metastasis detection in recurrent liver cancer, indicating potential false positives from benign post-treatment fibrosis.

Key Points

To evaluate the complementary performance of 18F-FAPI PET/CT compared with 18F-FDG PET/CT and MRI for diagnosing recurrent hepatocellular carcinoma and extrahepatic metastases.
Evaluated a 71-year-old male presenting with suspected recurrence five years following radical resection of hepatocellular carcinoma.
Performed multimodal diagnostic evaluations using 18F-FDG PET/CT, 18F-FAPI PET/CT, and MRI to identify and characterize intrahepatic and extrahepatic lesions.
18F-FDG PET/CT detected two iso-metabolic right peritoneal lesions and a hypo-metabolic lesion in the right liver.
18F-FAPI PET/CT demonstrated elevated tracer uptake along the hepatic capsule and peritoneum, showing superior sensitivity over 18F-FDG for identifying small peritoneal metastases.
A wedge-shaped zone of high 18F-FAPI uptake adjacent to a necrotic radiofrequency ablation zone was confirmed as a false-positive finding caused by benign postoperative stromal fibrosis.

Cite This Study

Chen et al. (2022) studied this question.

synapsesocial.com/papers/6a72b60226a7f98052de6e50 https://doi.org/10.2147/cmar.s374916

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Implication

Case report reveals 18F-FAPI PET/CT improves peritoneal metastasis detection in recurrent liver cancer, indicating potential false positives from benign post-treatment fibrosis.

Different Features of 18F-FAPI, 18F-FDG PET/CT and MRI in the Evaluation of Extrahepatic Metastases and Local Recurrent Hepatocellular Carcinoma (HCC): A Case Report and Review of the Literature

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Implication

Key Points

Cite This Study

Different Features of 18F-FAPI, 18F-FDG PET/CT and MRI in the Evaluation of Extrahepatic Metastases and Local Recurrent Hepatocellular Carcinoma (HCC): A Case Report and Review of the Literature

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Key Points

Cite This Study

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