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January 8, 2015Nicotine & Tobacco ResearchOpen Access

Varenicline as a Cause of Suicidal Outcomes

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Why the study?

Does varenicline increase the risk of suicidal outcomes in smokers?

Population

Smokers, including those with psychiatric problems

Comparison

Varenicline vs Placebo, prescribed bupropion, or…

Design

Systematic_review

Authors

JHJohn R. Hughes

Discussion

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Overview

Reassures on varenicline suicide safety for smoking cessation; challenges postmarketing warnings in favor of controlled evidence.

Structured PICO

Does varenicline increase the risk of suicidal outcomes in smokers?

P
Population
Smokers, including those with psychiatric problems
I
Intervention
Varenicline
C
Comparator
Placebo, prescribed bupropion, or over-the-counter nicotine medications
O
Outcome
Suicidal outcomessafety

This systematic review suggests that varenicline does not significantly increase the risk of suicidal outcomes, indicating that clinical warnings should reflect findings from more valid research designs rather than just postmarketing reports.

Cite This Study

John R. Hughes (2015) studied this question.

synapsesocial.com/papers/6a72b6088031ec7bb1dd740chttps://doi.org/10.1093/ntr/ntu275
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of varenicline versus bupropion and risk of psychiatric adverse events2013 · 30 citations
  2. 2Effects of Varenicline on Smoking Cessation in Adults With Stably Treated Current or Past Major Depression2013 · 133 citations
  3. 3Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report2008 · 739 citations