Nebivolol Inhibits Superoxide Formation by NADPH Oxidase and Endothelial Dysfunction in Angiotensin II–Treated Rats

Male Wistar rats with angiotensin II-induced hypertension (1 mg/kg per day for 7 days), and in vitro models (heart membranes from angiotensin II-infused animals, Nox1 and cytosolic subunit-transfected and phorbol ester-stimulated HEK293 cells)

Nebivolol (10 mg/kg per day in vivo; in vitro treatment)

Metoprolol (10 mg/kg per day in vivo; in vitro treatment) and atenolol (in vitro)

Endothelial function, superoxide formation, NO bioavailability, and NADPH oxidase activity and expressionsurrogate