Why the study?
Does coadministration of losartan with mineralocorticoid receptor antagonists improve cardiac sarcolemmal Na+-K+ pump function in hyperaldosteronemia?
Does coadministration of losartan with mineralocorticoid receptor antagonists improve cardiac sarcolemmal Na+-K+ pump function in hyperaldosteronemia?
Coadministration of angiotensin receptor blockers and mineralocorticoid receptor antagonists has an additive beneficial effect on cardiac Na+-K+ pump function in hyperaldosteronemia, providing a mechanistic basis for their combined use in heart failure.
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Losartan plus MR antagonists additively restores pump function in aldosterone models; leaves open translation to human HF therapy.
Mihailidou et al. (2002) studied this question.
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