Why the study?
Does Rac1 knockout or apocynin treatment prevent myocardial remodeling and dysfunction in a mouse model of type 1 diabetes?
Population
Mice with streptozotocin-induced diabetes and isolated adult rat cardiomyocytes cultured in high glucose.
Comparison
Cardiomyocyte-specific Rac1 knockout or apocynin… vs Wild-type diabetic mice treated with vehicle.
Design
Preclinical
Follow-up
2 months
Authors
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May support Rac1/NADPH oxidase inhibition in diabetic cardiomyopathy models; hypothesis-generating and should not yet change practice.
Does Rac1 knockout or apocynin treatment prevent myocardial remodeling and dysfunction in a mouse model of type 1 diabetes?
Inhibition of Rac1 and NADPH oxidase prevents myocardial remodeling and dysfunction in a mouse model of diabetic cardiomyopathy, suggesting a potential therapeutic target.
Li et al. (2010) studied this question.
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