Why the study?
Does targeted overexpression of MnSOD improve cardiac mitochondrial function and reduce diabetic cardiomyopathy in a type 1 diabetic mouse model?
Population
Type 1 diabetic mouse model
Comparison
Targeted overexpression of the mitochondrial… vs Type 1 diabetic mouse model without MnSOD…
Design
Preclinical
Authors
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Hypothesis-generating for MnSOD-targeted therapy in diabetic cardiomyopathy; human studies required before clinical translation.
Does targeted overexpression of MnSOD improve cardiac mitochondrial function and reduce diabetic cardiomyopathy in a type 1 diabetic mouse model?
Overexpression of the mitochondrial antioxidant protein MnSOD protects against oxidative damage and prevents diabetic cardiomyopathy in a preclinical model.
Shen et al. (2006) studied this question.
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