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December 1, 1979Development

The effect of prolonged decompaction on the development of the preimplantation mouse embryo

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Population

Preimplantation mouse embryos

Comparison

Prolonged decompaction using a rabbit antiserum… vs Removal of the antibody at the 32-cell stage

Design

Preclinical

Authors

MJMartin H. JohnsonGolden Jubilee National HospitalJCJoy ChakrabortyUniversity of BurdwanAHAlan H. HandysideUniversity of Kent

Discussion

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Implication

Alerts embryologists to decompaction timing risks in culture; leaves open translation to human blastocyst viability.

Structured PICO

P
Population
Preimplantation mouse embryos
I
Intervention
Prolonged decompaction using a rabbit antiserum to a mouse embryonal carcinoma cell line
C
Comparator
Removal of the antibody at the 32-cell stage
O
Outcome
Development of blastocysts and generation of inner cell mass (ICM) and trophectoderm lineages

Prolonged decompaction beyond the 32-cell stage in mouse embryos disrupts normal blastocyst development, reducing functional inner cell mass.

Cite This Study

Johnson et al. (1979) studied this question.

synapsesocial.com/papers/6a72b6e8f44fa9f079e017fchttps://doi.org/10.1242/dev.54.1.241
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