October 28, 2013International Journal of Molecular SciencesOpen Access

AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway

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Population

In vivo models of sustained cardiac stress and in vitro phenylephrine stimulated neonatal rat ventricular…

Design

Preclinical

Authors

HYHongjuan YuHarbin Medical University WTWardit TigchelaarUniversity Medical Center Groningen BLBo LüNingbo No. 2 Hospital

Discussion

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Implication

AKIP1-Akt signaling merits further hypertrophy research in models; leaves open in vivo relevance and any clinical translation.

Structured PICO

Population

In vivo models of sustained cardiac stress (pressure overload, myocardial infarction) and in vitro phenylephrine (PE) stimulated neonatal rat ventricular cardiomyocytes (NRVCs)

Intervention

AKIP1 overexpression and Akt inhibition

Outcome

Hypertrophic growth responses (cell size, cytoskeletal organization, protein synthesis) and Akt phosphorylationsurrogate

AKIP1 is induced in hypertrophic hearts and stimulates adaptive cardiomyocyte growth via the Akt signaling pathway.

Cite This Study

Yu et al. (2013) studied this question.

synapsesocial.com/papers/6a72b71c75498292b70bb015 https://doi.org/10.3390/ijms141121378

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AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider