Salivary Amylase as a Biomarker of Periodontal Diseases

This is the authors' abstract. We don't add key points for this paper.

Salivary amylase, an enzyme primarily involved in starch digestion, has gained attention as a potential biomarker for periodontal diseases due to its role in modulating bacterial growth within the oral cavity. This review examines the role of salivary amylase in periodontal diseases, focusing on its diagnostic potential and clinical relevance. The study utilized online databases, including PubMed, Scopus, and Medline, alongside manual searches to ensure comprehensive coverage. Studies investigating salivary amylase levels in individuals with periodontal diseases over the past decade were included. Exclusion criteria encompassed non-English articles, non-peer-reviewed studies, review articles, animal studies, and research involving children (<17 years old), individuals with systemic diseases, or smokers. A total of 289 articles were identified through database and manual searches, with eight studies meeting the inclusion criteria for final analysis. Among the included studies, several reported significant differences in salivary amylase levels between individuals with gingivitis, chronic periodontitis, and healthy periodontium. Some studies failed to find significant differences in salivary amylase levels between periodontal disease groups and healthy controls. Certain studies emphasized the influence of periodontal treatment on salivary amylase levels. Salivary amylase shows promise as a biomarker for assessing periodontal health and monitoring treatment outcomes. Salivary amylase demonstrates potential as a biomarker for periodontal health and post-treatment outcomes, though inconsistencies in findings highlight the need for standardized methodologies.