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Experimental study demonstrates that nitrogen-substituents regulate stability and emission in novel acridinium esters, highlighting pathways for optimized chemiluminescent probes.
Several novel N-substituted acridinium esters 7-16 containing a 10-methyl, 10-dodecyl, or 10-(ω-[succinimidyloxycarbonyl]alkyl) group have been synthesized and their chemiluminescent properties have been tested. Their chemiluminescent efficiencies and hydrolytic stabilities have been found to be affected by the characteristics of the group on the nitrogen atom. Dibromo-substituted leaving groups slightly accelerate the chemiluminescence process.
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Smith et al. (2022) studied this question.
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