Why the study?
Does inflammaging, frailty, or dependence status increase circulating extracellular vesicle concentration in elderly individuals?
Does inflammaging, frailty, or dependence status increase circulating extracellular vesicle concentration in elderly individuals?
Contrary to expectations based on general inflammatory episodes, the basal proinflammatory status of aging (inflammaging) and frailty do not increase total circulating extracellular vesicle concentrations.
No increase in circulating EVs with inflammaging or frailty; leaves open whether EV subtypes or cargo differ in aging.
In the last decades extracellular vesicles (EVs) have emerged as key players for intercellular communication. In the case of inflammation, several studies have reported that EV levels are increased in circulation during inflammatory episodes. Based on this, we investigated whether aging results in elevated EV number, as a basal proinflammatory status termed "inflammaging" has been described in aged individuals. Moreover, we also hypothesized that frailty and dependence conditions of the elderly could affect EV concentration in plasma. Results showed that inflammaging, frailty or dependence status do not result in EV increase, at least in the total number of EVs in circulation. These results open a new perspective for investigating the role of EVs in human aging and in the inflammaging process.
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Alberro et al. (2016) studied this question.
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