What question did this study set out to answer?

To evaluate the direct vascular contraction and relaxation effects of polyoxyethylated vehicles used for intravenous and oral cyclosporin A formulations in isolated rat aorta.

August 1, 1990Clinical Science

Direct Vascular Effects in the Rat of the Vehicles Used for the Intravenous and Oral Administration of Cyclosporin A

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Authors

CACarlos AmorenaConsejo Nacional de Investigaciones Científicas y Técnicas ACAriel F. CastroUniversity of Concepción AMAixa MüllerMoffitt Cancer Center

Discussion

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Implication

Preclinical study demonstrates that cyclosporin A formulation vehicles impair endothelium-dependent vasorelaxation in isolated rat aorta, indicating inhibition of relaxing factor synthesis.

Key Points

To evaluate the direct vascular contraction and relaxation effects of polyoxyethylated vehicles used for intravenous and oral cyclosporin A formulations in isolated rat aorta.
Tested isolated rat aortic ring responses to polyoxyethylated vehicles alone and to commercially available intravenous cyclosporin A.
Assessed resting tension, noradrenaline-induced contractions, and relaxations stimulated by acetylcholine, carbamylcholine, ATP, sodium nitroprusside, or bumetanide.
Evaluated the mechanistic roles of cyclooxygenase products and the nitric oxide pathway using indomethacin and L-arginine (3 x 10^-5 mol/l).
Vehicles did not alter resting vascular tension, noradrenaline-induced contractions, or endothelium-independent relaxation mediated by sodium nitroprusside or bumetanide.
All tested vehicle preparations decreased endothelium-dependent relaxation induced by acetylcholine, carbamylcholine, or ATP by approximately 66%, an effect that occurred without cyclosporin A.
The vehicle-induced inhibition of endothelium-dependent relaxation was unaffected by indomethacin and was completely reversed by co-treatment with L-arginine (3 x 10^-5 mol/l).

Cite This Study

Amorena et al. (1990) studied this question.

synapsesocial.com/papers/6a72bbd7e5469ee92be28ac4 https://doi.org/10.1042/cs0790149

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Implication

Preclinical study demonstrates that cyclosporin A formulation vehicles impair endothelium-dependent vasorelaxation in isolated rat aorta, indicating inhibition of relaxing factor synthesis.

Direct Vascular Effects in the Rat of the Vehicles Used for the Intravenous and Oral Administration of Cyclosporin A

Discussion

Member takes

Implication

Key Points

Cite This Study

Direct Vascular Effects in the Rat of the Vehicles Used for the Intravenous and Oral Administration of Cyclosporin A

Discussion

Member takes

Implication

Key Points

Cite This Study

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