Why the study?
Diffuse cystic lesions are a rare pulmonary manifestation of NSCLC and can lead to misdiagnosis as pulmonary Langerhans cell histiocytosis.
Diffuse cystic lesions can be a rare manifestation of non-small cell lung cancer, highlighting the need for accurate diagnosis to avoid misdiagnosis as pulmonary Langerhans cell histiocytosis.
NSCLC may mimic PLCH with progressive diffuse cystic lesions; extends recognized imaging spectrum and supports TBCB for diagnosis.
BACKGROUND: Cystic airspace is an uncommon imaging manifestation involved in non-small lung cancer (NSCLC). Diffuse cystic lesion is even rarer as pulmonary manifestation of NSCLC. In the present study, we reported a rare case of NSCLC associated with progressive diffusion of cystic lesions misdiagnosed as Pulmonary langerhans cell histocytosis (PLCH), finally diagnosed by transbronchial cryobiopsy (TBCB). CASE PRESENTATION: A 52-year-old woman was admitted to our hospital due to cough and dyspnea. High-resolution computed tomography (HRCT) presented diffuse cystic shadow mostly, concomitantly with nodular densities in bilateral lungs. A lung biopsy revealed poorly differentiated adenocarcinoma with vascular tumor emboli. The epidermal growth factor receptor (EGFR) mutation on exon 18 (G719X, G719) was detected by mutation test. The patient received treatment of tyrosine kinase inhibitor (afatinib). CONCLUSIONS: Diffuse cystic lesion can be a rare manifestation of lung cancer. It was important to improve the recognition of diffuse cystic lung diseases to avoid misdiagnosis.
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Gui et al. (2020) studied this question.
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