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July 1, 1986Annals of Neurology

Myopathy caused by a deficiency of Ca2+‐adenosine triphosphatase in sarcoplasmic reticulum (Brody's disease)

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Population

4 male patients from two families with impaired skeletal muscle relaxation that rapidly worsened during…

Design

Case_series

Authors

GKGeorge KarpatiJCJeffrey H. M. CharukSCStirling Carpenter

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Overview

Confirms type 2 fiber-specific Ca2+-ATPase deficiency in Brody's disease; leaves open therapeutic implications pending larger studies.

Structured PICO

P
Population
4 male patients from two families with impaired skeletal muscle relaxation that rapidly worsened during exercise (Brody's disease)
I
Intervention
Muscle biopsies examined by biochemical and microscopic immunocytochemical techniques
O
Outcome
Ca2+-ATPase concentration and ATP-dependent Ca2+ transport rate in skeletal musclesurrogate

Brody's disease is characterized by a deficiency of Ca2+-ATPase in the sarcoplasmic reticulum of type 2 muscle fibers, explaining the impaired muscle relaxation.

Cite This Study

Karpati et al. (1986) studied this question.

synapsesocial.com/papers/6a72bd3f75498292b70bb32chttps://doi.org/10.1002/ana.410200108
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Also Consider

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