Theoretical scaling laws for the mammalian cardiovascular system may allow for extrapolation of physiological measurements and drug dosages across species and age groups.
May enable allometric scaling for pediatric dosing; leaves open prospective validation before clinical use.
The modeling of the cardiovascular system of mammals is discussed within the framework of governing allometric relations and related scaling laws for mammals. An earlier theory of the writer for resting-state cardiovascular function is reviewed and standard solutions discussed for reciprocal quarter-power relations for heart rate and cardiac output per unit body mass. Variation in the basic cardiac process controlling heart beat is considered and shown to allow alternate governing relations. Results have potential application in explaining deviations from the noted quarter-power relations. The work thus indicates that the cardiovascular systems of all mammals are designed according to the same general theory and, accordingly, that it provides a quantitative means to extrapolate measurements of cardiovascular form and function from small mammals to the human. Various illustrations are included. Work described here also indicates that the basic scaling laws from the theory apply to children and adults, with important applications such as the extrapolation of therapeutic drug dosage requirements from adults to children.
No takes yet. Share an insight, caveat, or question.
Thomas H. Dawson (2014) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: