Pharmacological characterization of phosphoinositide-linked glutamate receptor excitation of hippocampal neurons
Structured PICO
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Population
CA1 pyramidal neurons (hippocampal neurons)
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Intervention
Pertussis toxin, 2-amino-3-phosphonopropionate (AP3) (1-2 mM), and phorbol 12,13-diacetate (1-1.5 microM) applied to neurons stimulated by trans-1-aminocyclopentyl-1,3-dicarboxylate (ACPD; 30 microM)
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Outcome
Membrane depolarization and inhibition of the slow afterhyperpolarizationsurrogate
The study provides evidence for heterogeneity among phosphoinositide-linked glutamate receptor responses in hippocampal neurons.
Authors
Discussion
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Implication
Hypothesis-generating for hippocampal mGluR heterogeneity; leaves open any clinical translation to human glutamate signaling.
Cite This Study
Stratton et al. (1990) studied this question.