Oxidative Stress and Protective Effect of Erythropoietin on Methotrexate-induced Esophageal Damage

Mesut Garipardıç; Vedat Bakan; Mehmet Davutoğlu; Hamide Sayar; Ergül Belge Kurutaş

doi:10.1097/mph.0b013e3181ccb678

February 27, 2010Journal of Pediatric Hematology/Oncology

Oxidative Stress and Protective Effect of Erythropoietin on Methotrexate-induced Esophageal Damage

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Why the study?

Does erythropoietin prevent methotrexate-induced esophageal damage in a rat model?

Structured PICO

Does erythropoietin prevent methotrexate-induced esophageal damage in a rat model?

P

Population

24 female Sprague-Dawley rats

I

Intervention

Subcutaneous injections of methotrexate (5 mg/kg) and erythropoietin (2000 IU/kg) once daily for 4 consecutive days

C

Comparator

Subcutaneous injections of methotrexate (5 mg/kg) alone (control) or 0.2 mL of 0.9% NaCl (sham)

O

Outcome

Oxidative damage (levels of malondialdehyde and nitric oxide, activities of superoxide dismutase and catalase) and histologic damage to esophageal tissue at the fifth daysurrogate

Erythropoietin demonstrates significant preventive effects against methotrexate-induced oxidative damage in the esophagus of a rat model.

Implication

EPO attenuated MTX esophageal injury in rats; hypothesis-generating and should not yet change pediatric practice.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Garipardıç et al. (2010) studied this question.

synapsesocial.com/papers/6a72c094febe604dd70ac0e7 https://doi.org/10.1097/mph.0b013e3181ccb678

View Full Paper

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Oxidative Stress and Protective Effect of Erythropoietin on Methotrexate-induced Esophageal Damage

Structured PICO

Implication

Discussion

Cite This Study

Oxidative Stress and Protective Effect of Erythropoietin on Methotrexate-induced Esophageal Damage

Structured PICO

Implication

Discussion

Cite This Study

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