Why the study?
Does sequential IPV and OPV improve immunogenicity compared to IPV alone in healthy infants?
Does sequential IPV and OPV improve immunogenicity compared to IPV alone in healthy infants?
Sequential IPV and OPV schedules induce stronger immunogenicity than IPV alone in healthy infants, supporting WHO recommendations during the transition period.
Sequential IPV-OPV schedules yield stronger immunogenicity than IPV alone in infants; confirms advantage during transition to IPV-only regimens.
BACKGROUND: The emergence of vaccine-associated paralytic poliomyelitis has become an ongoing burden of poliomyelitis. During this special period from OPV to IPV-only immunization schedule, we did a meta-analysis to compare the immunogenicity of sequential IPV and OPV versus IPV alone in healthy infants. METHODS: This systematic review and meta-analysis was registered at international prospective register of systematic reviews (PROSPERO), and the number was CRD42017054889. We performed it as described. RESULTS: Finally, 6 articles were qualified for our review. The results showed that seroconversion rates against all 3 serotype polioviruses were non-inferior and Geometric mean antibody titers (GMTs) were superior in sequential schedules compared with IPV-only schedule. Thus, the sequential vaccination schedules could induce a stronger immunogenicity. CONCLUSIONS: To decrease vaccine-associated and vaccine-derived poliomyelitis, it is a reasonable option to select sequential schedules during this special transition from OPV to IPV-only immunization schedule, which coincides with the current WHO recommendations.
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Tang et al. (2018) studied this question.
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