Polymorphisms in the lymphocyte-specific upstream promoter of the prolactin gene, specifically the PRL-1149 G allele, may explain the association between hyperprolactinaemia and systemic lupus erythematosus.
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PRL-1149 G allele may link hyperprolactinemia to SLE; hypothesis-generating and should not yet change practice.
Stevens et al. (2001) studied this question.
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