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May 1, 1999Critical Care Medicine

An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyl-L-arginine hydrochloride (546C88), in patients with septic shock

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Authors

RGRobert F. GroverSimpson UniversityDZDavid ZaccardelliUniversity of North Carolina at Chapel HillGCGene ColiceAstraZeneca (United States)

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Grover et al. (1999) studied this question.

synapsesocial.com/papers/6a72c181a528af2d65c48622https://doi.org/10.1097/00003246-199905000-00025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Induction of NG-monomethyl-L-arginine uptake: a mechanism for differential inhibition of NO synthases?1995 · 134 citations
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  4. 4Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide1992 · 1,643 citations
  5. 5Role of nitric oxide in the vascular dysfunction of septic shock1995 · 65 citations