Key result
Oxidized LDL drives arterial inflammation and atherogenesis, highlighting a potential role for antioxidant therapies.
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A brief review of recent findings regarding the role of oxidized low-density lipoproteins (Ox-LDL) in atherogenesis. Lipid peroxidation and oxidative damage to LDL make arteries susceptible to chronic inflammation, which is known to cause alterations in arterial gene expression and promote lesion development. Treatment protocols implementing antioxidants for preventing cardiovascular diseases are suggested.
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Seppo Ylä‐Herttuala (1999) conducted a review in Atherogenesis and cardiovascular diseases. Oxidized low-density lipoproteins (Ox-LDL) and antioxidants was evaluated on Atherogenesis and lesion development. Oxidized low-density lipoproteins promote chronic arterial inflammation and lesion development in atherogenesis, suggesting a preventive role for antioxidant therapy.
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