Why the study?
Surgery and anesthesia activate neuroendocrine pathways with dangerous hemodynamic effects, prompting investigation into whether preoperative oral midazolam could reduce postoperative pain and rescue analgesia in patients undergoing laparoscopic cholecystectomy.
Does preoperative oral midazolam reduce postoperative pain scores in patients undergoing laparoscopic cholecystectomy?
Population
Patients undergoing laparoscopic cholecystectomy (control n=32)
Comparison
7.5mg preoperative oral midazolam vs control
Design
Single-blinded randomized controlled study
Follow-up
24 hours
Authors
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Preoperative oral midazolam may reduce postoperative pain; leaves open its routine use pending larger confirmatory RCTs.
Does preoperative oral midazolam reduce postoperative pain scores in patients undergoing laparoscopic cholecystectomy?
Preoperative oral midazolam 7.5 mg does not effectively lower postoperative pain scores in patients undergoing laparoscopic cholecystectomy.
Siddiqui et al. (2022) studied this question.
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