Population
Transfected cell lines
Comparison
Reporter gene construct with the firefly… vs Construct without the 5'-UTR
Design
Preclinical
Authors
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Does not alter clinical practice; leaves open the IRES role in cardiac gap junction regulation in vivo.
The study identifies a functional internal ribosome entry site in the 5'-UTR of connexin43 mRNA, providing insight into the regulation of this major gap junction protein.
Schiavi et al. (1999) studied this question.
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