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February 23, 2017Medicine & Science in Sports & ExerciseOpen Access

Muscle Metaboreflex Control of Sympathetic Activity in Obstructive Sleep Apnea

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Why the study?

Is obstructive sleep apnea associated with altered muscle metaboreflex control of sympathetic activity?

Population

31 sedentary individuals with no comorbidities, including 17 with obstructive sleep apnea defined by…

Comparison

30% handgrip static exercise for 3 min followed… vs Control group without OSA undergoing the same…

Design

Cross-sectional

Authors

LULinda Massako UenoRGRenan Segalla GuerraTGThiago T. Goya

Discussion

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Overview

OSA may augment metaboreflex sympathetic control; hypothesis-generating for mechanisms linking sleep apnea to hypertension.

Structured PICO

Is obstructive sleep apnea associated with altered muscle metaboreflex control of sympathetic activity?

P
Population
31 sedentary individuals with no comorbidities (age = 52 ± 1 yr, body mass index = 28 ± 1 kg/m²), including 17 with obstructive sleep apnea (OSA) defined by polysomnography and 14 controls without OSA.
I
Intervention
30% handgrip static exercise for 3 min followed by 2 min of post-handgrip muscle ischemia (PHMI)
C
Comparator
Control group without OSA undergoing the same physiological protocol
O
Outcome
Muscle sympathetic nerve activity (MSNA) response during post-handgrip muscle ischemia (PHMI)surrogate

Obstructive sleep apnea is associated with decreased metaboreflex control of muscle sympathetic nerve activity, though muscle vasodilation during exercise remains preserved.

Cite This Study

Ueno et al. (2017) studied this question.

synapsesocial.com/papers/6a72c271fe4101aa97e0ee96https://doi.org/10.1249/mss.0000000000001242
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